TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being

TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being

The steroidogenic 18 kDa translocator protein (TSPO) is an emerging, attractive therapeutic tool for several pathological conditions of the nervous system. Here, 13 high affinity TSPO ligands belonging to our previously described N,N-dialkyl-2-phenylindol-3-ylglyoxylamide (PIGA) class were evaluated for their potential ability to affect the cellular Oxidative Metabolism Activity/Proliferation i...

Understanding Human Well - being

Targeting mitochondrial energy metabolism with TSPO ligands.

The translocator protein (18 kDa) (TSPO) resides on the outer mitochondrial membrane where it is believed to participate in cholesterol transport and steroid hormone synthesis. Although it is almost ubiquitously expressed, what TSPO does in non-steroidogenic tissues is largely unexplored. Recent studies report changes in glucose homoeostasis and cellular energy production when TSPO function is ...

Ethical imperatives of teaching stress control to promote well-being

Human well-being: concepts and conceptualizations

Economic measures of income have ignored large areas of human well-being and are poor measures of well-being in the areas to which they attend. Despite increased recognition of those distortions, ‘GNP per capita continues to be regarded as the quintessential indicator of a country’s living standard’ (Partha Dasgupta). Well-being seems to have intuitive plausibility as a concept, but in practice...